Fig. 3.

Teneligliptin effects on the antioxidant gene expression in HUVECs cultured under HG/HM conditions. Total cellular RNA was isolated from HUVECs after 21 days in culture in NG, HG or NM. Cells were treated with different doses of teneligliptin (0.1, 1.0 and 3.0 µmol/L) or sitagliptin (0.5 µmol/L). mRNA encoding for the indicated genes was assessed by qRT-PCR and expressed relative to GAPDH or ACTB. *p < 0.05 vs. NG. #p < 0.05 vs. HG. $p < 0.05 vs. HM. Bars represent mean ± SEM of six independent experiments