Table 3.

The inhibitory effect of vancomycin (VAN) or teicoplanin (TEC) in combination with one of four cephalosporins at a series of 2-fold dilution for 13 methicillin-resistant Staphylococcus aureus isolates with a high-cefazolin MIC.

VAN MIC	1/2x	1/4x	1/8x	1/16x	1/32x	1/64x	1/128x	1/256x	1/512x
CFZ MIC
1/2x	13	12	10	10	9	9	9	8	4
1/4x	10	5	2	1	1	0	0	0	0
1/8x	0	0	0	0	0	0	0	0	0
1/16x	0	0	0	0	0	0	0	0	0
CMZ MIC
1/2x	13	13	13	11	9	8	5	5	1
1/4x	11	8	5	4	2	0	0	0	0
1/8x	5	1	0	0	0	0	0	0	0
1/16x	1	0	0	0	0	0	0	0	0
CTX MIC
1/2x	13	13	13	13	13	11	10	9	8
1/4x	13	9	9	8	4	1	0	0	0
1/8x	8	0	0	0	0	0	0	0	0
1/16x	1	0	0	0	0	0	0	0	0
CPM MIC
1/2x	13	13	9	7	6	6	6	5	2
1/4x	6	4	0	0	0	0	0	0	0
1/8x	1	0	0	0	0	0	0	0	0
1/16x	0	0	0	0	0	0	0	0	0
TEC MIC	1/2x	1/4x	1/8x	1/16x	1/32x	1/64x	1/128x	1/256x	1/512x
CFZ MIC
1/2x	13	13	12	12	11	11	11	9	8
1/4x	11	11	4	1	0	0	0	0	0
1/8x	2	0	0	0	0	0	0	0	0
1/16x	0	0	0	0	0	0	0	0	0
CMZ MIC
1/2x	13	13	12	11	11	11	7	3	0
1/4x	10	8	5	4	3	3	1	0	0
1/8x	2	0	0	0	0	0	0	0	0
1/16x	1	0	0	0	0	0	0	0	0
CTX MIC
1/2x	13	13	13	10	8	6	4	4	3
1/4x	13	5	2	2	1	0	0	0	0
1/8x	7	0	0	0	0	0	0	0	0
1/16x	0	0	0	0	0	0	0	0	0
CPM MIC
1/2x	13	12	12	10	9	9	7	6	6
1/4x	7	5	0	0	0	0	0	0	0
1/8x	2	0	0	0	0	0	0	0	0
1/16x	0	0	0	0	0	0	0	0	0

MIC, minimal inhibitory concentration; CFZ, cefazolin; CMZ, cefmetazole; CTX, cefotaxime; CPM, cefepime. The numeric data indicate the isolate numbers with no visible growth overnight at different drug concentration combinations.