Table 1.
Summary of clinical and sociodemographic data of study participants.
| Controls (n = 12) | Bacterial keratitis (BK) | Fungal keratitis (FK) | BK vs. FK | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Microarray Cohort (n = 7) | Validation Cohort (n = 18) | p-value | Microarray Cohort (n = 8) | Validation Cohort (n = 165) | p-value | Microarray cohort p-value | Validation Cohort p-value | ||
| Gender, No. Male (%) | 7 (58%) | 7 (100%) | 13 (72%) | 0.12 | 4 (50%) | 105 (64%) | 0.44 | 0.03 | 0.47 |
| Age, median (IQR), years | 82 (76.5–90) | 67 (60–75) | 55 (35–62) | 0.02 | 52.5 (43–62.5) | 50 (36.5–58) | 0.44 | 0.04 | 0.41 |
| Symptom duration, median (range), days | – | 15 (7–20) | 10 (2–90) | 0.19 | 14.5 (2–43) | 7 (1–90) | 0.12 | 1.00 | 0.12 |
| Uncorrected visual acuity*, median (IQR) | – | 1.9 (1.8–1.9) | 1.7 (1.7–1.8) | 0.01 | 1.85 (1.8–1.9) | 1.8 (0.56–1.8) | <0.01 | 0.62 | 0.86 |
| Median stromal infiltrate size** (mm), (IQR) | – | 7.0 (5.7–8.5) | 3.8 (3.2–5.1) | <0.01 | 5.8 (4.3–9.2) | 4.4 (3.5—5.5) | 0.04 | 0.68 | 0.58 |
| Perforation | – | 7 (100%) | 1 (5%) | 0.01 | 3 (38%) | 19 (11%) | <0.01 | 0.01 | 0.44 |
*
Visual Acuity measured in logMAR units:>1.0, unable to read any letters on chart; 1.8, able to count fingers only; 1.9, able to see hand movements only; 2.0, perception of light only.
**
Stromal infiltrate size calculated as geometric mean of longest stromal infiltrate diameter and its perpendicular measurement (mm).
All p-values generated by comparing microarray study participants vs. validation cohort, within bacterial or fungal keratitis groups.