Table 1.

Overview of different SNCA mutations and clinical features

Variable	SNCA mutation
	p.A53T	p.A30P	p.E46K	G51D	H50Q	Duplication	Triplication
References	17, 28–34	34, 35	22	36, 37	23, 36, 38	39–42	25, 43, 44
Mean age of onset	47 yr	60 yr	60 yr	40 yr	58 yr	50 yr	40 yr
Mean time from motor onset to death	8 yr	4 yr in 1 individual, others alive	10 yr	8 yr	8 yr	15 yr	7 yr
Motor features*
Tremor	↓*	↓	↑	↓	-	-	↑
Rigidity	-*	↓	↑	-	-	-	↑
Bradykinesia	-	↓	↑	-	-	-	↑
Postural instability	-	↓	↑	-	-	-	↑
Non-motor features*
Dementia	↑*	-	↑	↑	↑	-	↑
Depression	↑	-	-	↑	-	-	-
Autonomic disturbances	↑	-	-	↑	-	-	-
Sensitivity to levodopa therapy	+*	?	With hallucinations and fluctuation of consciousness at therapeutic doses of L-dopa	+, induce involuntary movement	+	+	-

This table was assembled using updated genetic insights of different SNCA mutations according to the reference by Kasten and Klein. [21]

^*different SNCA mutations’ motor/non-motor features compared with typical Parkinson’s disease symptoms. ↓: means moderate, -: means no difference/not sensitive, ↑: means severe, +: means sensitive, ?: means unknown.