Algorithm for cardiac monitoring in patients receiving trastuzumab. LVEF, left ventricular ejection fraction. Reprinted from: G. Curigliano, D. Cardinale, T. Suter, G. Plataniotis, E. de Azambuja, M.T. Sandri, C. Criscitiello, A. Goldhirsch, C. Cipolla & F. Roila, Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines, Annals of Oncology, 2012, Volume 23 (supplement 7), pages vii155–Vii166, by permission of Oxford University Press.