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. 2017 Apr 15;31(8):774–786. doi: 10.1101/gad.294991.116

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© 2017 Amankulor et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — Human muIDH1 gliomas had repressed tumor-associated immune systems. (A,B) FACS analysis using wtIDH1 (n = 10) and muIDH1 (n = 6) human glioma tissues to quantify tumor-associated immune cells. Error bars show the standard error of mean (SEM). Analysis was done using Student's t-test. (C) Summary of the number of up-regulated and down-regulated genes between two glioma groups: wtIDH1 human low-grade gliomas (LGGs, black, n = 91), human muIDH1 astrocytomas (AS, red; n = 248), and human muIDH1 oligodendrogliomas (OD, blue; n = 169), (D) Summary of the number of gene ontology (GO) terms associated with up-regulated and down-regulated genes between two glioma groups. (E) Immune-related GO terms and corresponding P-values that are associated with the down-regulated genes in muIDH1 human gliomas.