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. 2017 Apr 15;31(8):774–786. doi: 10.1101/gad.294991.116

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© 2017 Amankulor et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — muIDH1 mouse gliomas resembled muIDH1 human gliomas. (A) Survival plots of muIDH1 versus wtIDH1 mouse gliomas with different genomic backgrounds (Ntva_Ink4a/Arf^+/+, Ntva_Ink4a/Arf^+/−, and Ntva_Ink4a/Arf^−/−) (Hambardzumyan et al. 2009). (B) Table showing median survivals and P-values. (C) 2-HG concentrations in murine gliomas. Metabolites from murine glioma tissues were extracted followed by DATAN derivatization. 2-HG was measured with liquid chromatography-mass spectrometry. Seven and 11 metabolite extracts were used for the wtIDH1 and muIDH1 mouse glioma groups, respectively. Error bars show the standard deviation (SD). Analysis was done using Student's t-test. (D) CpG island methylation analysis using reduced representation bisulfite sequencing (RRBS). n = 4 muIDH1; n = 2 wtIDH1.