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. 2017 Apr 15;31(8):830–844. doi: 10.1101/gad.295741.116

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© 2017 Ho et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — XPC modulates TDG-binding dynamics to DNA in vivo. (A) Survival probability of an individual TDG-Halo molecule being bound as a function of time. Individual molecules were tracked using single-molecule imaging over consecutive frames and binned by their total length in cells cotransfected with SNAP-NLS or SNAP-XPC or transduced with lentiviruses containing a control NT shRNA or shRNA against XPC (shXPC). Bold lines represent the mean probability; shaded regions denote the 95% confidence interval. (B) Quantification of TDG DNA-bound residence time using a two-exponential decay model after correction for photobleaching using Halo-H2B (see Supplemental Fig. S7K). Error bars depict the standard deviation of the model fit.