Table 7.
Essential oila | Methodb | Species strainc | Solventd | Resulte | Main componentsf | Reference |
---|---|---|---|---|---|---|
Abies balsamea (fir) | MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | β-Pinene (31.00%), bornyl acetate (14.90%), δ-3-carene (14.20%) | [99] |
Abies holophylla (Manchurian fir) | C. albicans (B02630) | DMSO | >2.20 mg/mL | Bicyclo[2.2.1]heptan-2-ol (28.05%), δ-3-carene (13.85%), α-pinene (11.68%), camphene (10.41%) | [111] | |
Abies koreana (Korean fir) | Bornyl ester (41.79%), camphene (15.31%), α-pinene (11.19%) | |||||
| ||||||
Achillea millefolium subsp. millefolium (yarrow) | MIC | C. albicans (ATCC 10239) | Tween 80 | 4.50 mg/mL | Eucalyptol (24.60%), camphor (16.70%), α-terpineol (10.20%) | [112] |
Achillea setacea (bristly yarrow) | 1.12 mg/mL | Sabinene (10.80%), eucalyptol (18.50%) | [113] | |||
| ||||||
Angelica archangelica (angelica) root | MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | α-Phellandrene (18.50%), α-pinene (13.70%), β-phellandrene (12.60%), δ-3-carene (12.10%) | [99] |
Angelica archangelica (angelica) seed | β-Phellandrene (59.20%) | |||||
| ||||||
Anthemis nobilis (chamomile) | MIC | C. albicans (ATCC 10231) | Acetone | 3.00 mg/mL | 2-Methylbutyl-2-methyl propanoic acid (31.50%), limonene (18.30%), 3-methylpentyl-2-butenoic acid (16.70%), isobutyl isobutyrate (10.00%) | [99] |
| ||||||
Apium graveolens (celery) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 1.00% v/v | NCR | [236] |
Artemisia dracunculus (tarragon) | MIC | Acetone | 2.00 mg/mL | Estragole (82.60%) | [99] | |
| ||||||
Boswellia carteri (frankincense) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 1.00% v/v | NCR | [236] |
Boswellia carteri (frankincense) (9 samples) | MIC | Acetone | 5.30–12.00 mg/mL | α-Pinene (4.80–40.40%), myrcene (1.60–52.40%), limonene (1.90–20.40%), α-thujene (0.30–52.40%), p-cymene (2.70–16.90%), β-pinene (0.30–13.10%) | [116] | |
Boswellia frereana (frankincense) (3 samples) | 6.00–12.00 mg/mL | α-Pinene (2.00–64.70%), α-thujene (0.00–33.10%), p-cymene (5.40–16.90%) | ||||
Boswellia neglecta (frankincense) | 1.80 mg/mL | NCR | [117] | |||
6.60 mg/mL | α-Pinene (43.40%), β-pinene (13.10%) | [116] | ||||
Boswellia papyrifera (frankincense) | 1.40 mg/mL | NCR | [117] | |||
Boswellia rivae (frankincense) | 4.00 mg/mL | |||||
Boswellia sacra (frankincense) (2 samples) | 8.00 mg/mL | α-Pinene (18.30–28.00%), α-thujene (3.90–11.20%), limonene (11.20–13.10%) | [116] | |||
Boswellia spp. (frankincense) (4 samples) | 6.00–8.00 mg/mL | α-Pinene (18.80–24.20%), limonene (11.70–19.00%) | ||||
Boswellia thurifera (frankincense) | 6.00 mg/mL | α-Pinene (28.00%), limonene (14.60%) | ||||
| ||||||
Cananga odorata (ylang-ylang) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 1.00% v/v | NCR | [236] |
MIC | Acetone | 2.00 mg/mL | Bicyclosesquiphellandrene (19.50%), β-farnesene (13.90%) | [99] | ||
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.25–0.50% | NCR | [237] | |
Cananga odorata (ylang-ylang) heads | MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | Benzyl acetate (31.90%), linalool (27.00%), methyl benzoate (10.40%) | [99] |
| ||||||
Canarium luzonicum (elemi) | MIC | C. albicans (ATCC 10231) | Acetone | 3.00 mg/mL | Limonene (41.90%), elemol (21.60%), α-phellandrene (11.40%) | [99] |
| ||||||
Carum carvi (caraway) | MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | Limonene (27.60%), carvone (67.50%) | [99] |
| ||||||
Carum carvi (caraway) | MIC | C. albicans | DMSO | ≤1.00 μg/mL | DL-Limonene (53.35%), β-selinene (11.08%), β-elemene (10.09%) | [118] |
| ||||||
Cedrus atlantica (cedar wood) | ADM90 | C. albicans | Tween 80 | >2.00% v/v | NCR | [236] |
| ||||||
Cinnamomum camphora (camphor) | ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.50% | NCR | [237] |
| ||||||
Cinnamomum cassia (cinnamon) | MAC80 | C. albicans (ATCC90029) | n.m. | 0.17 μL/mL | trans-Cinnamaldehyde (92.20%) | [238] |
| ||||||
Cinnamomum cassia (cinnamon) | MIC | C. albicans | DMSO | ≤1.00 μg/mL | trans-Caryophyllene (17.18%), eugenol (14.67%), linalool L (14.52%), trans-cinnamyl acetate (13.85%), cymol (11.79%), cinnamaldehyde (11.25%) | [118] |
| ||||||
Cinnamomum zeylanicum (cinnamon) | ADM | C. albicans | DMSO | 0.08 μL/mL | NCR | [232] |
MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | Eugenol (80.00%) | [99] | |
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.01% | NCR | [237] | |
| ||||||
Citrus aurantium (petitgrain) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 0.25% v/v | NCR | [236] |
MIC | Acetone | 2.00 mg/mL | Linalyl acetate (54.90%), linalool (21.10%) | [99] | ||
| ||||||
Citrus bergamia (bergamot) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 1.00% v/v | NCR | [236] |
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 1.00–2.00% | [237] | ||
| ||||||
Citrus grandis (grapefruit) | MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | Limonene (74.80%) | [99] |
| ||||||
Citrus medica limonum (lemon) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 2.00% v/v | NCR | [236] |
ADM | C. albicans | DMSO | 2.50 μL/mL | [232] | ||
MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | [99] | ||
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.50–1.00% | [237] | ||
| ||||||
Citrus limon (lemon), aromatic art | MAC | C. albicans (clinical strain C31) | Tween 80 | 0.03% | Limonene (22.42%), isopropyl myristate (42.78%) | [239] |
Citrus limon (lemon), Avicenna | 0.60% | Limonene (42.03%), β-pinene (15.15%) | ||||
Citrus limon (lemon) -Vera Nord | Limonene (23.39%), trans-citral (15.52%), cis-citral (19.41%) | |||||
| ||||||
Citrus sinensis (orange) | MAC | C. albicans (ATCC 10231) | 0.1% ethanol | 3.75 mg/L | NCR | [121] |
MIC | Acetone | 2.00 mg/mL | Limonene (93.20%) | [99] | ||
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 1.00% | NCR | [237] | |
| ||||||
Commiphora guidotti (myrrh) | MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | (E)-β-Ocimene (52.60%), α-santalene (11.10%), (E)-bisabolene (16.00%) | [117] |
Commiphora myrrha (myrrh) | 1.50 mg/mL | Furanogermacrene (15.90%), furanoeudesma-1,3-diene (44.30%) | ||||
4.00 mg/mL | Furanoeudesma-1,3-diene (57.70%), lindestrene (16.30%) | [99] | ||||
| ||||||
Coriandrum sativum (coriander) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 0.25% v/v | NCR | [236] |
MIC | C. albicans (CBS 562 and 4 clinical isolates) | n.m. | 0.02–0.06 mg/mL | Decanal (10.97%), 1-decanol (15.30%), 2-dodecenol (11.26%) | [240] | |
| ||||||
Cupressus sempervirens (cypress) | MIC | C. albicans (ATCC 10231) | Acetone | 4.00 mg/mL | α-Pinene (41.20%), δ-3-carene (23.70%) | [99] |
| ||||||
Cymbopogon citratus (lemongrass) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 0.12% v/v | NCR | [236] |
ADM | C. albicans (SP-14) | Sodium taurocholate | 5.00 μL/mL | Citral (72.80%) | [125, 126] | |
MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | Geranial (44.80%) | [99] | |
MIC | C. albicans | DMSO | ≤1.00 μg/mL | Geranial (47.34%), β-myrcene (16.53%), Z-citral (8.36%) | [118] | |
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.06% | NCR | [237] | |
| ||||||
Cymbopogon martinii (palmarosa) | MIC | C. albicans (CBS 562 and 4 clinical isolates) | n.m. | 0.06–0.25 mg/mL | NCR | [240] |
ADM | C. albicans (SP-14) | Sodium taurocholate | 2.00 μL/mL | Geraniol (61.60%) | [125, 126] | |
C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.12–0.15% | NCR | [237] | ||
C. albicans (clinical samples) | 0.08% | [75] | ||||
| ||||||
Cymbopogon nardus (citronella) | ADM90 | C. albicans (ATCC10231) | Tween 80 | 0.25% v/v | NCR | [236] |
MIC | Acetone | 0.75 mg/mL | Citronellal (38.30%), geraniol (20.70%), citronellol (18.80%) | [99] | ||
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.50–1.00% | NCR | [237] | |
| ||||||
Cymbopogon winterianus (citronella grass) | MIC | C. albicans (CBS 562 and 4 clinical isolates) | n.m. | 0.50–1.00 mg/mL | NCR | [240] |
| ||||||
Daucus carota (carrot seed) | MIC | C. albicans (ATCC10231) | Acetone | 3.00 mg/mL | Carotol (44.40%) | [99] |
MAC | 2% DSMO | 1.25–2.50 μL/mL | Sabinene (28.30–33.80%), limonene (6.50–11.80%), elemicin (6.20–26.00%) | [241] | ||
≥20.00 μL/mL (v/v) | β-Bisabolene (17.6%), carotol (25.1), 11αH-himachal-4-en-1β-ol (21.6%) | [242] | ||||
5.00–10.00 μL/mL (v/v) | β-Bisabolene (51.00%), (E)-methyl isoeugenol (10.00%) | |||||
α-Pinene (37.9%), geranyl acetate (15%) | ||||||
>20.00 μL/mL (v/v) | Geranyl acetate (65.00%) | |||||
| ||||||
Eucalyptus camaldulensis (eucalyptus) | ADM | C. albicans | DMSO | 5.00 μL/mL | NCR | [232] |
| ||||||
Eucalyptus fruticetorum (eucalyptus) | ADM90 | C. albicans (ATCC10231) | Tween 80 | 1.00% v/v | NCR | [236] |
| ||||||
Eucalyptus globulus (eucalyptus) | ADM | C. albicans (clinical samples) | Tween 20 | 0.05% | NCR | [75] |
MIC90 | C. albicans (ATCC 90028) | Tween 80 | 10.00 mg/mL | 1,8-Cineol (81.93%) | [128] | |
ADM | C. albicans (SP-14) | Sodium taurocholate | 5.00 μL/mL | Cineole (23.20%) | [125, 126] | |
MIC | C. albicans (ATCC 10231) | Acetone | 1.50 mg/mL | 1,8-Cineole (58.00%), α-terpineol (13.20%) | [99] | |
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 1.50% | NCR | [237] | |
MIC | C. albicans (ATCC 10231) | Acetone | 1.00 mg/mL | NCR | [130] | |
| ||||||
Eucalyptus radiata (eucalyptus) | MIC | C. albicans (ATCC 10231) | Acetone | 1.00 mg/mL | 1,8-Cineole (65.7% ± 9.5), α-terpineol (12.8% ± 4.4) | [130] |
Eucalyptus camaldulensis (eucalyptus) | 0.50 mg/mL | NCR | ||||
Eucalyptus citriodora (eucalyptus) | 1.00 mg/mL | |||||
Eucalyptus smithii (eucalyptus) | ||||||
Eucalyptus dives (eucalyptus) | ||||||
| ||||||
Eucalyptus intertexta (eucalyptus) | MAC | C. albicans (ATCC 10231) | 10% DSMO | 7.80 μg/mL | NCR | [131] |
Eucalyptus largiflorens (eucalyptus) | 125.00 μg/mL | NCR | ||||
| ||||||
Eugenia caryophyllus (clove) | ADM | C. albicans (clinical samples) | Tween 20 | 0.33% | NCR | [75] |
Foeniculum vulgare (fennel) | MIC | C. albicans | DMSO | ≤1.00 μg/mL | trans-Anethole (33.3%), DL-limonene (19.66%), carvone (12.03%) | [118] |
Foeniculum dulce (fennel) | MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | E-Anethole (79.10%) | [99] |
| ||||||
Hyssopus officinalis (hyssop) | MIC | C. albicans (ATCC 10231) | Acetone | 1.00 mg/mL | Isopinocamphone (48.70%), pinocamphone (15.50%) | [99] |
| ||||||
Geranium dissectum (geranium) | MIC | C. albicans | DMSO | ≤1.00 μg/mL | β-Citronellol (25.45%), geraniol (13.83%) | [118] |
| ||||||
Jasminum nudiflorum (jasmine) | ADM | C. albicans (clinical samples) | Tween 20 | >3.00% | NCR | [75] |
Juniperi aetheroleum (juniper) | MAC80 | C. albicans (MFBF) | n.m. | 1.00% v/v | α-Pinene (29.17%), β-pinene (17.84%), sabinene (13.55%) | [135] |
Juniperus chinensis (Chinese juniper) | ADM | C. albicans (clinical samples) | Tween 20 | 2.00% | NCR | [75] |
Juniperus communis (juniper berry) | MIC90 | C. albicans (ATCC 90028) | Tween 80 | 20.00 mg/mL | α-Pinene (39.76%) | [128] |
Juniperus communis (juniper) | ADM90 | C. albicans (ATCC10231) | 2.00% v/v | NCR | [236] | |
Juniperus communis ssp. alpina (juniper), berries | MAC | C. albicans (clinical strain D5) | 2% DMSO | 1.25–2.50 μL/mL | α-Pinene (77.40%) | [243] |
Juniperus communis subsp. alpina (juniper) | C. albicans (ATCC 10231) | 5.00–10.00 μL/mL | ||||
2.50 μL/mL | Sabinene (26.20%), α-pinene (12.90%), limonene (10.40%) | [244] | ||||
Juniperus virginiana (juniper) | MIC | C. albicans (ATCC 10231) | Acetone | 1.50 mg/mL | Thujopsene (29.80%), cedrol (14.90%), α-cedrene (12.40%) | [99] |
Juniperus virginiana (juniper), berries | 2.00 mg/mL | α-Pinene (20.50%), myrcene (13.70%), bicyclosesquiphellandrene (10.70%) | ||||
Juniperus virginiana (juniper) | ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 3.00% | NCR | [237] |
Juniperus turbinata (juniper), berries | MAC | C. albicans (ATCC 10231) | 2% DMSO | 10.00–20.00 μL/mL | α-Pinene (66.70%) | [243] |
C. albicans (clinical strain D5) | 5.00 μL/mL | |||||
Juniperus turbinata (juniper), leaf | C. albicans (ATCC 10231) | 2% DMSO | 5.00 μL/mL | α-Pinene (48.20%), β-phellandrene (23.10%) | ||
C. albicans (clinical strain D5) | 1.25 μL/mL | |||||
Juniperus oxycedrus (cade juniper) | ADM | C. albicans (clinical samples) | Tween 20 | NI | NCR | [75] |
| ||||||
Juniperus oxycedrus ssp. oxycedrus (cade), leaf | MAC | C. albicans (ATCC 10231) | 2% DMSO | 1.25–25.00 μL/mL | α-Pinene (65.50%) | [243] |
C. albicans (clinical strain D5) | 0.32–0.64 μL/mL | |||||
Juniperus oxycedrus ssp. oxycedrus (cade), berries | C. albicans (ATCC 10231) | 2% DMSO | 10.00–20.00 μL/mL | α-Pinene (54.70)%, myrcene (17.80%), germacrene D (10.40%) | ||
C. albicans (clinical strain D5) | 5.00 μL/mL | |||||
| ||||||
Kunzea ericoides (Kānuka) | MAC | C. albicans (ATCC 10231) | Tween 80 | >2.00% v/v | α-Pinene (61.60%) | [137] |
MIC | C. albicans (ATCC 10231) | Acetone | 4.00 mg/mL | α-Pinene (26.20–46.70%), p-cymene (5.80–19.10%) | [138] | |
Laurus nobilis (bay) | 0.75 mg/mL | Eugenol (57.20%), myrcene (14.30%), chavicol (12.70%) | [99] | |||
| ||||||
Lavandula angustifolia (lavender) | ADM | C. albicans (clinical samples) | Tween 20 | >3.00% | NCR | [75] |
MIC | C. albicans (ATCC 10231) | Acetone | 5.70 mg/mL | Linalool (30.80%), linalyl acetate (31.30%) | [140] | |
3.00 mg/mL | Linalyl acetate (36.70%), linalool (31.40%), terpinen-4-ol (14.90%) | [99] | ||||
ADM90 | C. albicans (ATCC 10231) | Tween 80 | 0.50% v/v | NCR | [236] | |
0.25% v/v | ||||||
| ||||||
Lavandula officinalis (lavender) | MIC | C. albicans (ATCC 10231) | DMSO | ≤1.00 μg/mL | δ-3-Carene (17.14%), α-fenchene (16.79%), diethyl phthalate (13.84%) | [118] |
| ||||||
Lavandula pedunculata (French lavender) | MAC | C. albicans (ATCC 10231) | 2% DMSO | 2.50 μL/mL | 1,8-Cineole (2.40–55.50%), fenchone (1.30–59.70%), camphor (3.60–48.00%) | [245] |
Lavandula stoechas (French lavender) | Fenchone (37.00%) and camphor (27.30%) | [246] | ||||
Lavandula viridis (yellow lavender) | 1,8-Cineole (34.50%–42.2%), camphor (13.40%) | [247] | ||||
| ||||||
Leptospermum scoparium (manuka) | MAC | C. albicans (ATCC 10231) | Tween 80 | >2.00% v/v | (−)-(E)-Calamenene (14.50%), leptospermone (17.60%) | [137] |
MIC | Acetone | 8.00 mg/mL | Eudesma-4(14),11-diene (6.2–14.5%), α-selinene (5.90–13.5%), (E)-methyl cinnamate (9.2–19.5%) | [138] | ||
| ||||||
Litsea cubeba (May Chang) | MIC | C. albicans (ATCC 10231) | Acetone | 6.00 mg/mL | Geranial (45.60%), nerol (31.20%) | [99] |
| ||||||
Matricaria chamomilla (German chamomile) | MIC | C. albicans (ATCC 10231) | Acetone | 0.50 mg/mL | Bisabolene oxide A (46.90%), β-farnesene (19.20%) | [99] |
ADM | C. albicans (clinical samples) | Tween 20 | NI | NCR | [75] | |
| ||||||
Melaleuca alternifolia (tea tree) | ADM | C. albicans (clinical samples) | Tween 20 | 0.73% | NCR | [75] |
MIC | C. albicans (KEM H5) | n.m. | 0.13% (v/v) | Terpinen-4-ol (39.80%), γ-terpinene (17.80%) | [149, 150] | |
ADM90 | C. albicans (ATCC10231) | Tween 80 | 0.25% v/v | NCR | [236] | |
ADM | 0.20% v/v | Terpinen-4-ol (42.80%), γ-terpinene (18.20%) | [115] | |||
MIC | C. albicans (NCYC 854) | n.m. | 0.25% v/v | NCR | [145] | |
C. albicans (fluconazole- and itraconazole-susceptible isolates) | Tween 80 | 0.06–0.50% v/v | Terpinen-4-ol (42.35%), γ-terpinene (20.65%) | [248] | ||
C. albicans (fluconazole- and/or itraconazole-resistant isolates; six isolates were cross-resistant) | 0.25–0.50% v/v | |||||
ADM | C. albicans (NRRL y-12983) | n.m. | 3.50 mg/mL | NCR | [249] | |
C. albicans (ATCC 14053) | ||||||
C. albicans (NRRL y-869) | ||||||
C. albicans (NRRL y-22077) | 1.75 mg/mL | |||||
C. albicans (ATCC 10231) | 3.50 mg/mL | |||||
MIC | C. albicans (NRRL 12983) | 4.73 mg/mL | γ-Terpinene (16.30%), terpinen-4-ol (30.30%) | [61] | ||
C. albicans (ATCC 14053) | ||||||
C. albicans (ATCC 90028) | ||||||
C. albicans (NRRL 22077) | 2.30 mg/mL | |||||
C. albicans (ATCC 10231) | 4.73 mg/mL | |||||
C. albicans (ATCC 10231) | Acetone | 3.70 mg/mL | Terpinen-4-ol (38.60%), γ-terpinene (21.60%) | [140] | ||
MAC | C. albicans (ATCC 10231) | Tween 80 | 0.30% v/v | α-Terpinene (11.40%), γ-terpinene (22.50%), terpinen-4-ol (35.20%) | [137] | |
MIC | C. albicans (ATCC 10231) | Acetone | 1.50 mg/mL | Terpinen-4-ol (49.30%), γ-terpinene (16.90%) | [99] | |
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.12–0.25% | NCR | [237] | |
| ||||||
Melaleuca cajuputi (cajuput) | MIC90 | C. albicans (ATCC 90028) | Tween 80 | 2.50 mg/mL | 1,8-Cineol (67.60%) | [128] |
MAC | C. albicans (ATCC10231) | 0.40% v/v | 1,8-Cineole (55.50%) | [137] | ||
| ||||||
Melaleuca quinquenervia (niaouli) | MAC | C. albicans (ATCC10231) | Tween 80 | 0.40% v/v | 1,8-Cineole (61.20%) | [137] |
| ||||||
Melaleuca viridiflora (niaouli) | MIC | C. albicans (ATCC10231) | Acetone | 1.75 mg/mL | 1,8-Cineole (45.90%), α-terpinene (21.00%) | [99] |
| ||||||
Mentha piperita (peppermint) | ADM90 | C. albicans (ATCC10231) | Tween 80 | 0.50% v/v | NCR | [236] |
MIC90 | C. albicans (ATCC 90028) | 0.30 mg/mL | 1,8-Cineol (12.06%), menthone (22.24%), menthol (47.29%) | [128] | ||
ADM | C. albicans (SP-14) | Sodium taurocholate | 5.00 μL/mL | Menthol (36.40%) | [125, 126] | |
MIC | C. albicans (ATCC 10231) | Acetone | 2.40 mg/mL | Menthone (18.20%), menthol (42.90%) | [140] | |
ADM | C. albicans (clinical isolate) | Tween 20 | 0.08% | NCR | [75] | |
MIC | C. albicans (clinical isolate) | DMSO | 0.31–0.63 mg/mL | Menthol (27.50–42.30%), menthone (18.40–27.90%) | [155] | |
C. albicans | ≤1.00 μg/mL | Menthone (40.82%), carvone (24.16%) | [118] | |||
C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | Menthol (47.50%), menthone (18.60%) | [99] | ||
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.25–0.30% | NCR | [237] | |
Mentha pulegium (peppermint) | MIC | C. albicans (ATCC 10231) | 10% DMSO | 1.00 μL/mL | Piperitone (38.00%), piperitenone (33.00%) | [250] |
Mentha rotundifolia (peppermint), Beja | C. albicans | Tween 80 | 0.80% v/v | β-Caryophyllene (26.67%), germacrene D (12.31%) | [50] | |
Mentha rotundifolia (peppermint), Bizerte | Pulegone (32.09%), piperitenone oxide (17.28%), 5-acetyl thiazole (11.26%) | |||||
| ||||||
Mentha spicata (spearmint) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 0.12% v/v | NCR | [236] |
| ||||||
Myrtus communis (myrtle) | MIC | C. albicans (ATCC 10231) | Acetone | 1.50 mg/mL | Myrtenyl acetate (28.20%), 1,8-cineole (25.60%), α-pinene (12.50%) | [99] |
Myrtus nivellei (Sahara myrtle) | MAC | C. albicans (ATCC 10231) | 2% DMSO | 1.25–2.50 μg/mL | 1,8-Cineole (37.50%), limonene (25.00%) | [251] |
| ||||||
Ocimum basilicum var. minimum (basil) | MIC | C. albicans (ATCC 11006) | DMSO | NI | Linalool (440%), 1,8-cineole (15.50%) | [252] |
Ocimum americanum (basil) | 5000.00 μg/mL | 1,8-Cineole (25.90%), (Z)-methyl cinnamate (29.40%) | ||||
Ocimum basilicum var. purpurascens (basil) | Linalool (41.50%), α-muurolol (11.80%) | |||||
Ocimum micranthum (basil) | 625.00 μg/mL | Eugenol (64.11%), β-caryophyllene (14.30%) | ||||
Ocimum selloi | 1250.00 μg/mL | Linalool (16.8%), anethole (52.2%) | ||||
| ||||||
Ocimum basilicum (basil) | MIC | C. albicans | n.m. | 30.00 μg/μL | Estragole (45.80%), linalool (24.20%) | [253] |
ADM90 | C. albicans (ATCC10231) | Tween 80 | 0.50% v/v | NCR | [236] | |
ADM | C. albicans (clinical samples) | Tween 20 | 1.50% | [75] | ||
MIC | C. albicans (ATCC 10231) | Acetone | 1.00 mg/mL | Linalool (54.10%) | [99] | |
MIC90 | n.m. | 95.00 μg/mL | Methyl chavicol (46.90%), geranial (19.10%), neral (15.15%) | [159] | ||
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 1.00% | NCR | [237] | |
| ||||||
Ocimum gratissimum (African basil) | MIC | C. albicans (clinical isolate) | n.m. | 750.00 μg/mL | Eugenol (67.00%) | [254] |
| ||||||
Ocimum sanctum (holy basil) | MIC90 | C. albicans (37 clinical isolates (5 resistant to fluconazole)) | 10% DMSO | 0.10–0.24 μL/mL | Methyl chavicol (44.63%), linalool (21.84%) | [255] |
C. albicans (ATCC 90028) | 0.25 μL/mL | |||||
C. albicans (ATCC 10261) | 0.20 μL/mL | |||||
C. albicans (ATCC 44829) | ||||||
ADM | C. albicans (clinical samples) | Tween 20 | 0.48% | NCR | [75] | |
| ||||||
Origanum majorana (marjoram) | MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | 1,8-Cineole (46.00%), linalool (26.10%) | [99] |
| ||||||
Origanum acutidens (Turkey oregano) | MIC | C. albicans (A117) | 10% DMSO | 125.00 μg/mL | Carvacrol (72.00%) | [161] |
| ||||||
Origanum microphyllum (oregano) | MIC | C. albicans | Tween 80 | 3.23 mg/mL | Terpinen-4-ol (24.86%), γ-terpinene (13.83%), linalool (10.81%) | [162] |
| ||||||
Origanum vulgare (oregano) | MIC | C. albicans | n.m. | 2.00 μg/μL | Carvacrol (61.30%), thymol (13.90%) | [253] |
ADM90 | C. albicans (ATCC10231) | Tween 80 | 0.12% v/v | NCR | [236] | |
ADM | C. albicans (NRRL y-12983) | n.m. | 0.70 mg/mL | NCR | [249] | |
C. albicans (ATCC 14053) | ||||||
C. albicans (NRRL y-869) | ||||||
C. albicans (NRRL y-22077) | ||||||
C. albicans (ATCC 10231) | ||||||
MIC | C. albicans (NRRL 12983) | Cymene (25.00%), cymenol (58.6.00%) | [61] | |||
C. albicans (ATCC 14053) | ||||||
C. albicans (ATCC 90028) | ||||||
C. albicans (NRRL 22077) | ||||||
C. albicans (ATCC 10231) | ||||||
| ||||||
Origanum vulgare subsp. hirtum (Greek oregano) | MAC | C. albicans (ATCC 10239) | 10% DMSO + Tween 80 | 85.30 μg/mL | Linalool (96.31%) | [165] |
Origanum vulgare subsp. vulgare (oregano) | 128.00 μg/mL | Thymol (58.31%), carvacrol (16.11%), p-cymene (13.45%) | ||||
| ||||||
Pelargonium graveolens (geranium) | ADM | C. albicans (NRRL y-12983) | n.m. | 0.70 mg/mL | NCR | [249] |
C. albicans (ATCC 14053) | ||||||
C. albicans (NRRL y-869) | ||||||
C. albicans (NRRL y-22077) | ||||||
C. albicans (ATCC 10231) | ||||||
MIC | C. albicans (NRRL 12983) | n.m. | 0.12 mg/mL | Citronellol (47.30%) | [61] | |
C. albicans (ATCC 14053) | ||||||
C. albicans (ATCC 90028) | ||||||
C. albicans (NRRL 22077) | ||||||
C. albicans (ATCC 10231) | n.m. | 0.06 mg/mL | ||||
C. albicans (ATCC 10231) | Acetone | 0.75 mg/mL | Citronellol (34.20%), geraniol (15.70%) | [99] | ||
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.12% | NCR | [237] | |
| ||||||
Perovskia abrotanoides (Russian sage) | MIC | C. albicans (ATCC 10231) | 10% DMSO | 8.00 μL/mL | Camphor (23.00%), 1,8-cineole (22.00%), α-pinene 12.00% | [167] |
| ||||||
Pimenta racemosa (West Indian bay) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 0.12% v/v | NCR | [236] |
| ||||||
Pimpinella anisum (anise) | MAC83 | C. albicans | n.m. | 1.00% v/v | Anethole, anisaldehyde, linalool | [256] |
MIC | DMSO | ≤1.00 μg/mL | Anethole (64.82%) | [118] | ||
| ||||||
Pinus sylvestris (pine) | MIC | C. albicans (ATCC 10231) | Acetone | 1.50 mg/mL | Bornyl acetate (42.30%), camphene (11.80%), α-pinene (11.00%) | [99] |
| ||||||
Piper nigrum (black pepper) | MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | β-Caryophyllene (33.80%), limonene (16.40%) | [99] |
| ||||||
Pogostemon patchouli (patchouli) | MIC | C. albicans (ATCC 10231) | Acetone | 1.50 mg/mL | Patchouli alcohol (37.30%), α-bulnesene (14.60%), α-guaiene (12.50%) | [99] |
| ||||||
Ricinus officinalis (rose) | ADM | C. albicans (clinical samples) | Tween 20 | >3.00% | NCR | [75] |
| ||||||
Rosa gallica (rose) | ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 1.00–2.00% | NCR | [237] |
| ||||||
Rosmarinus officinalis (rosemary) | MIC | C. albicans (ATCC 10231) | Tween 80 | 0.25% v/v | 1,8-Cineole (27.23%), α-pinene (19.43%), camphor (14.26%), camphene (11.52%) | [169] |
0.10% v/v | 1,8-Cineole (26.54%), α-pinene (20.14%), camphene (11.38%), camphor (12.88%) | [170] | ||||
C. albicans (MTCC 1637) | n.m. | 5.50 mg/mL | NCR | [171] | ||
C. albicans (10 antifungal-resistant isolates) | 2.75–5.50 mg/mL | |||||
C. albicans (ATCC 10231) | Acetone | 5.70 mg/mL | 1,8-Cineole (41.40%), α-pinene (13.30%), camphor (12.40%) | [140] | ||
2.00 mg/mL | 1,8-Cineole (48.00%) | [99] | ||||
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 1.00% | NCR | [237] | |
| ||||||
Salvia eremophila (sage) | MIC | C. albicans (ATCC 10231) | 10% DMSO | 13.00 μg/mL | Borneol (21.83%), α-pinene (18.80%), bornyl acetate (18.68%) | [174] |
Salvia officinalis (sage) | ADM90 | Tween 80 | 0.50% v/v | NCR | [236] | |
| ||||||
Salvia ringens (sage) | MIC | C. albicans | n.m. | 0.75 mg/mL | α-Pinene (12.85%), 1,8-cineole (46.42%) | [177] |
| ||||||
Salvia rosifolia (sage) (3 samples) | MIC | C. albicans | 20% DMSO | 500.00 μg/mL | α-Pinene (15.70–34.80%), 1,8-cineole (16.60–25.10%), β-pinene (6.70–13.50%) | [178] |
| ||||||
Salvia sclarea (clary sage) | MIC | C. albicans (13 clinical isolates and 1 reference strain ATCC 10231) | 1% DMSO | 128.00–256.00 μg/mL | Linalyl acetate (56.88%), linalool (20.75%) | [257] |
C. albicans (ATCC 10231) | Acetone | 0.88 mg/mL | Linalyl acetate (72.90%), linalool (11.90%) | [99] | ||
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 2.00% | NCR | [237] | |
| ||||||
Santalum album (sandalwood) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 0.06% v/v | NCR | [236] |
MIC | Acetone | 2.00 mg/mL | α-Santalol (32.10%) | [99] | ||
| ||||||
Santolina chamaecyparissus (santolina) | MIC | C. albicans (CBS 562 and 4 clinical isolates) | n.m. | 0.25–>1.00 mg/mL | NCR | [240] |
| ||||||
Styrax benzoin (benzoin) | MIC | C. albicans (ATCC 10231) | Acetone | 2.00 mg/mL | Cinnamyl alcohol (44.80%), benzene propanol (21.70%) | [99] |
| ||||||
Syzygium aromaticum (clove) | ADM90 | C. albicans (ATCC 10231) | Tween 80 | 0.12% v/v | NCR | [236] |
MIC | C. albicans (ATCC 10231) | Tween 80 | 0.13% v/v | Eugenol (68.52%), β-caryophyllene (19.00%), 2-methoxy-4-[2-propenyl]phenol acetate (10.15%) | [169] | |
DMSO | ≤1.00 μg/mL | Eugenol (84.07%), isoeugenol (10.39%) | [118] | |||
MAC | C. albicans (ATCC 10231) | DMSO | 0.64 μg/mL | Eugenol (85.30%) | [258] | |
C. albicans (clinical isolate D5) | ||||||
C. albicans (clinical isolate D1) | ||||||
MIC | C. albicans (ATCC 10231) | Acetone | 0.50 mg/mL | Eugenol (82.20%), eugenol acetate (13.20%) | [99] | |
ADM | C. albicans (ATCC 10231 and 3 clinical isolates) | Tween 20 | 0.12% | NCR | [237] | |
| ||||||
Tagetes minuta (Mexican marigold) | MIC90 | C. albicans (ATCC 10231) | n.m. | 115.00 μg/mL | Dihydrotagetone (33.90%), E-ocimene (19.90%), tagetone (16.10%) | [159] |
Tagetes patula (French marigold) | MIC | Acetone | 2.00 mg/mL | (E)-β-Ocimene (41.30%), E-tagetone (11.20%), verbenone (10.90%) | [99] | |
| ||||||
Thymus broussonetii (thyme) | MAC | C. albicans (CCMM L4) | n.m. | 0.25 mg/mL | Thymol (39.64%), carvacrol (21.31%), borneol (20.13%) | [259] |
| ||||||
Thymus capitatus (thyme) | MIC | C. albicans (ATCC 10231) | Tween 80 | 450.00 μg/mL | p-Cymene (26.40%), thymol (29.30%), carvacrol (10.80%) | [181] |
Thymus capitatus (thyme), commercial | α-Pinene (25.20%), linalool (10.30%), thymol (46.10%) | |||||
| ||||||
Thymus herba-barona (thyme) | MAC | C. albicans (ATCC 10231) | 2% DMSO | 0.32 μL/mL | Carvacrol (54.00%), thymol (30.20%) | [246] |
| ||||||
Thymus herba-barona (thyme), Limbara | MIC | C. albicans (ATCC 10231) | Tween 80 | 450.00 μg/mL | p-Cymene (27.60%), thymol (50.30%) | [181] |
Thymus herba-barona (thyme), Gennargentu | 225.00 μg/mL | Thymol (46.90%), carvacrol (20.60%) | ||||
Thymus magnus (thyme) | C. albicans (KCCM 11282) | Ethanol and Tween 80 | 0.39 mg/mL | Thymol (39.80%) | [260] | |
| ||||||
Thymus maroccanus (thyme) | MAC | C. albicans (CCMM L4) | n.m. | 0.25 mg/mL | Carvacrol (89.15%) | [259] |
Thymus mastichina subsp. mastichina (thyme) | C. albicans (ATCC 10231, H37, M1) | n.m. | 1.25–2.50 μL/mL | 1,8-Cineole (67.40%) | [261] | |
| ||||||
Thymus quinquecostatus (thyme) | MIC | C. albicans (KCCM 11282) | Ethanol and Tween 80 | 0.39 mg/mL | Thymol (41.70%), γ-terpinene (16.00%) | [260] |
| ||||||
Thymus schimperi (thyme) | ADM | C. albicans | DMSO | 0.16 μL/mL | NCR | [232] |
| ||||||
Thymus vulgaris (thyme) | MIC | C. albicans | n.m. | 4.00 μg/μL | Thymol (47.90%) | [253] |
MAC | C. albicans (ATCC 10231, H37, M1) | 0.16–0.32 μL/mL | Carvacrol (70.30%), p-cymene (11.70%) | [261] | ||
MIC | C. albicans (ATCC 10231) | Acetone | 2.40 mg/mL | Thymol (47.20%), p-cymene (22.10%) | [140] | |
1.00 mg/mL | p-Cymene (39.90%), thymol (20.70%) | [99] | ||||
| ||||||
Thymus x viciosoi (thyme) | MAC | C. albicans (clinical isolates M1, D5), C. albicans (ATCC 10231) | 1% DMSO | 0.04–0.64 μL/ mL | Carvacrol (30.0 0%), thymol (18.00 %), p-cymene (19.0 0%) | [262] |
Thymus zygis subsp. sylvestris (thyme) | C. albicans (ATCC 10231) | 2% DMSO | 0.32–1.25 μL/mL | p-Cymene (11.00–17.00%), γ-terpinene (3.80–11.50%), linalool (3.50–30.00%), geraniol (0.10–19.80%), thymol (5.20–23.80%), carvacrol (1.30–25.00%), geranyl acetate (0.50–20.80%) | [263] | |
Thymus zygis subsp. zygis (thyme) | C. albicans (ATCC 10231, H37, M1) | n.m. | NI | Thymol (39.60%), p-cymene (21.20%) | [261] | |
| ||||||
Vetiveria zizanioides/Andropogon muricatus (vetiver) | ADM | C. albicans (clinical samples) | Tween 20 | NI | NCR | [75] |
MIC | C. albicans (ATCC 10231) | Acetone | 1.75 mg/mL | Zizanol (13.60%), β-vetirenene (7.20%) | [99] | |
| ||||||
Zingiber officinalis (ginger) | ADM | C. albicans (clinical samples) | Tween 20 | 3.00% | NCR | [75] |
C. albicans (ATCC 10231 and 3 clinical isolates) | [237] |
aScientific name (common name), part of plant (if applicable).
bMIC: microdilution method; MAC: macrodilution method; ADM: agar dilution method, CTA: contact time assay.
cAmerican Type Culture Collection, Rockville, USA (ATCC); Colección Espanõla de Cultivos Tipo (CECT); collection of microorganisms of the Department of Microbiology (MFBF); culture collection of antibiotics-resistant microbes (CCRM); Eskişehir Osmangazi University, Faculty of Medicine, clinical isolate (OGU); Laboratorio de Microbiología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina (LM); Microbial Type Culture Collection (MTCC); Mycology Laboratory (LM); National Center of Industrial Microorganisms (NCIM); National Collection of Type Cultures, London, Great Britain (NCTC); Spanish Collection of Type Cultures (STCC).
dDMSO concentration was not included; n.m.: not mentioned.
eNI: no inhibition.
fNCR: no composition results reported.