Figure 4.

(A) ¹H NMR spectra of Tel22 in the absence and presence of Δ1a/Λ1a. The assays were measured in 10 mM Tris–KCl buffer containing 10% D₂O. (B) Telomerase inhibition by Δ1a/Λ1a by using TRAP assay. Line 1: no enantiomer; Line 2–5: PCR products in the presence of 0.2, 0.5, 1, 2 μM Δ1a, respectively; Line 6–9: PCR products in the presence of 0.2, 0.5, 1, 2 μM Λ1a, respectively. (C) Schematic illustration of the chiral enantiomer selectively interacts with human telomeric hybrid G-quadruplex DNA.