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. 2017 Apr 8;45(9):5026–5035. doi: 10.1093/nar/gkx244

Table 4. Stabilization effect of Δ1a and Λ1a on different telomeric G-quadruplex DNA in K+ containing buffera.

Telomeric DNA Structure DNA Tm (°C) +Δ1a ΔTm (°C) +Λ1a ΔTm (°C)
Human (Tel22) Hybrid 54.6 ± 0.3 10.8 ± 0.3 0.2 ± 0.2
Oxytrichab Antiparallel 61.6 ± 0.2 −5.0 ± 0.5 −4.7 ± 0.4
Tetrahymenab Hybrid 58.2 ± 0.1 0.7 ± 0.3 0.8 ± 0.3
Tel22-TTT Hybrid 64.8 ± 0.3 0.2 ± 0.3 0.4 ± 0.2

aMelting assays were carried out in 10 mM Tris buffer containing 10 mM KCl at pH 7.2. DNA is 3 μM in strand. The concentration of the Ligands is equivalent with corresponding DNA. The values were the average of three independent measurements.

bThe Tm of the was measured in 1 mM K+ containing buffer.