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. 2017 Mar 21;45(9):5586–5601. doi: 10.1093/nar/gkx186

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — (A) Comparison of residual dipolar couplings (RDCs) measured by encoding C-H splittings along the ¹³C or ¹H dimension. Shown is the root-mean-square-deviation (RMSD) and Pearson's correlation coefficient (R²). (B) Correlation plot between sugar RDCs measured in A₂-DNA and ¹D_CH A₆-DNA (blue/green) or A₆-DNA^m1A16 (red/black). The A₆-DNA and A₆-DNA^m1A16 RDCs are normalized by scaling factors of 0.85 and 0.90 units, respectively, to account for differences in alignment. (C and D) Correlation plot between RDCs measured in unmodified and m¹A16 modified duplexes: (C) A₆-DNA versus A₆-DNA^m1A16 and (D) A₂-DNA versus A₂-DNA^m1A16, with the different bond vectors colored as shown in the inset. The A₂-DNA^m1A16 data are normalized by scaling factor of 0.90 units to account for differences in alignment. (E) Best-fitting A₆-DNA^m1A16 RDCs to the refined A₆-DNA structure and (F) A₆-DNA RDCs to the refined A₆-DNA^m1A16 structure. Error bar denotes one-standard deviation in RDC measurement.