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. 2017 Mar 15;45(9):5577–5585. doi: 10.1093/nar/gkx158

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Schematic representation of the TREX-2 complex that is formed around a Sac3 scaffold (red). The TREX-2 complex can be broadly subdivided into three regions. The most N-terminal region of Sac3 (N-region) and its homologues (such as GANP from Homo sapiens) contain FG-nucleoporin-like motifs (7). The middle region (M-region, also called PCI-region), in which Sac3 (red) forms a complex with Thp1 (green) and Sem1 (yellow). In this region both Sac3 and Thp1 have PCI folds based on a winged helix domain (WH) and a stack of helical TPR-like motifs (15,16). The juxtaposition of the winged helix domains together with an extended patch of positive charge forms a nucleic acid binding platform (16) and this region also interacts with the Mediator complex (15). In the CID-region, residues ∼720–805 of Sac3 interact with one Cdc31 chain (orange) and two Sus1 chains (blue) in Saccharomyces cerevisiae and mediates binding to NPCs (17,18).