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. 2017 Mar 15;45(9):5577–5585. doi: 10.1093/nar/gkx158

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Crystal structure of the Sac3^60-550:Thp1:Sem1 complex. (A and B) In addition to the structures of Sac3 residues 255–551 (grey), Thp1 (blue) and Sem1 (yellow) determined previously (15,16), the crystal structure of the Sac3^60-556:Thp1:Sem1 complex showed an extension of the Sac3 TPR repeat region (green) containing three additional helices, together with a novel extended loop (red) that linked the base of the Sac3 TPR region (green) to the N-terminal region of Thp1. (C and D) Charge distribution on the surface of the Sac3^60-556:Thp1:Sem1 complex (blue is positive, red is negative charge). There is an extensive region of positive charge stretching from the winged-helix region of both Sac3 and Thp1 (towards the top of the structure) down the distal region of Sac3 together with a distinct positively-charged patch towards the base of Thp1. These positively-charged areas are on the opposite side of the complex to the linker containing Sac3 residues 90–125.