Figure 4.
Sac3 residues 90–125 form an extended loop linking the distal end of the TPR region to Thp1. (A and B) Illustration of how the loop (red) stretches out from Sac3 (grey) to encircle the N-terminal region of the Thp1 PCI region (blue) with which it makes an extensive number of contacts and buries 1528 Å2 of surface area. Except for a small helix (residues 89–95), the residues in the loop lack regular secondary structure. (C) Schematic illustration of the interactions between residues in the Sac3 extended loop (red) and Thp1 (blue).