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. 2017 Mar 15;45(9):5577–5585. doi: 10.1093/nar/gkx158

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Contributions of different regions of Sac3 to mRNA nuclear export. Levels of nuclear accumulation of polyA⁺ RNA with different Sac3 variants were assessed using FISH with Cy3-labelled 30 nt oligo-(dT) probes. Sac3Δ90 showed 8% of cells with increased nuclear staining, which was similar to SAC3 cells (6%); sac3Δ125 cells showed a slight increase in nuclear staining (19%), whereas most sac3Δ250 cells (88%) showed nuclear accumulation of polyA⁺ RNA similar to that seen with sac3 NULL cells (86%), indicting that the nuclear export of mRNA had been impaired by this deletion.