Figure 2.

(a) The pedigree of this family. Squares indicate males; circles indicate females. Black symbols indicate patients with CPP. Symbols with a black point inside indicate asymptomatic carriers. White indicates patients without MKRN3 mutations. The arrow indicates the proband. (b) The position of the MKRN3 mutation in relation to genomic structure. The box indicates the exon. Black indicates the coding region; white indicates the untranslated regions. (c) Sanger sequencing chromatograms of the genomic region surrounding the MKRN3 mutation. The results are shown for the patient (left) and her family members (rightl). CPP, central precocious puberty.