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. 2017 Apr 6;18(2):105–108. doi: 10.1038/gene.2017.5

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Copyright © 2017 The Author(s)

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Putative regulatory element containing rs924080 and rs11578380 downstream of IL23R shows silencer activity. (a) Cartoon representation of IL23R and IL12RB2 promoter and putative regulatory element location (Chr1:67,759,931-67,761,417). ENCODE data from UCSC Genome Browser: DNase I hypersensitivity in Th17 cells, Th1 cells and Jurkat cells. (b) The transcriptional activity of rs924080 or rs11578380 compared to the minimal promoter pGL4minP (set to 1) was measured by luciferase reporter assays in Jurkat cells. The values of relative luciferase activity are expressed as mean±s.e.m. of four repeat experiments each carried out in triplicate. Student's t-test was used. minP, minimal promoter.