Table 2. Conditional analysis of SNP associations at IL23R–IL12RB2 intergenic region.
Positiona | Conditional SNP | Risk/protective | SNP | P | OR | RAF (case/control) | LD (r2/D′) with conditional SNP |
---|---|---|---|---|---|---|---|
Chr1:67706208 | rs11209026 | G/A | rs11209032 | 2 × 10−8 | 1.2 | 0.96/0.93 | 0.03/0.97 |
rs6677188 | <3 × 10−3 | 0.9 | 0.01/0.87 | ||||
rs924080 | 2 × 10−3 | 0.9 | 0.07/0.94 | ||||
rs11578380 | 2 × 10−4 | 1.1 | 0.04/0.94 | ||||
Chr1:67740342 | rs11209032 | A/G | rs11209026 | <9 × 10−14 | 0.6 | 0.37/0.33 | 0.03/0.97 |
rs6677188 | 0.2 | 1.0 | 0.17/1 | ||||
rs924080 | 0.3 | 1.0 | 0.38/1 | ||||
rs11578380 | 0.8 | 1.0 | 0.5/0.95 | ||||
Chr1:67760140 | rs924080 | T/C | rs11209026 | 9 × 10−14 | 0.6 | 0.58/0.54 | 0.07/0.94 |
rs11209032 | 3 × 10−6 | 1.2 | 0.38/1 | ||||
rs6677188 | 0.05 | 1.1 | 0.43/1 | ||||
rs11578380 | 0.06 | 1.1 | 0.61/0.95 | ||||
Chr1:67761365 | rs11578380 | G/C | rs11209026 | <4 × 10−14 | 0.6 | 0.47/0.44 | 0.04/0.94 |
rs11209032 | 1 × 10−5 | 1.2 | 0.5/0.95 | ||||
rs6677188 | 0.3 | 1.0 | 0.23/0.89 | ||||
rs924080 | 0.1 | 0.9 | 0.61/0.95 |
Abbreviations: Chr., chromosome; LD, linkage disequilibrium; OR, odds ratio; RAF, risk allele frequency; SNP, single-nucleotide polymorphism.
NCBI Build 37 human genome coordinates.