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. 2017 May 9;8:15068. doi: 10.1038/ncomms15068

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Copyright © 2017, The Author(s)

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Foxp3⁺ Treg cells in BM regulate the activation status of cytotoxic T cells and maintain the function of BM environment including ICAM1⁺perivascular cells. Activated T cells after Treg cells depletion could abrogate IL-7 secretion from ICAM1⁺ perivascular cells resulting in a defective B-cell differentiation from HSC.