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. 2017 Apr 10;7(4):e260. doi: 10.1038/nutd.2017.13

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Copyright © 2017 The Author(s)

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Selective loss of adipose mass in response to CR. (a) C57BL/6 male mice at least 12 weeks of age and 25 g were either fed AL or 75 % of the average daily standard chow intake. Mice were weighed daily and percent body weight change from starting body mass was calculated. Arrows mark early and late phases of weight loss (days 3 and 12) that are used in subsequent experiments. n=8 Two-way ANOVA (F_16,192=79.47, P<0.0001). Tukey's multiple comparisons (*P<0.0001 day 0 compared to day 3 on CR, *P<0.0001 day 3 compared to day 12 on CR). (b) Total adipose weight of dissected adipose depots following 0, 3 or 12 days of CR. The contribution of individual depots to the total dissected adipose mass is shown. Pink=retroperitoneal, red= epididymal, gray=inguinal and black= intrascapular brown. One-way ANOVA (F_2,21=24.42, P<0.0001) Tukey's multiple comparisons (P<0.0001 day 0 compared to day 12). (c) Dissected epididymal adipose mass after 0, 3 or 12 days of CR. One-way ANOVA (F_2,21=22.54, P<0.0001) Tukey's multiple comparisons (*P=0.05 day 0 compared to day 3, ****P<0.0001 day 0 compared to day 12). (d) Percent change in epididymal adipose mass compared to the average of CR day 0. One-way ANOVA (F_2,21=22.54, P<0.0001) Tukey's multiple comparisons (*P=0.05 day 0 compared to day 3, ****P<0.0001 day 0 compared to day 12). (e) Dissected retroperitoneal adipose mass after 0, 3 or 12 days of CR. One-way ANOVA (F_2,21=21.54, P<0.0001) Tukey's multiple comparisons (***P=0.0001 day 0 compared to day 12). (f) Percent change in retroperitoneal adipose mass compared to the average of CR day 0. One-way ANOVA (F_2,21=21.54, P<0.0001) Tukey's multiple comparisons (****P<0.0001 day 0 compared to day 12). (g) Dissected subcutaneous adipose mass after 0, 3 or 12 days of CR. One-way ANOVA (F_2,21=6.95, P=0.0048) Tukey's multiple comparisons (**P=0.0048 day 0 compared to day 12). (h) Percent change in inguinal adipose mass compared to the average of CR day 0. **P=0.0034 day 0 compared to day 12. (i) Dissected intrascapular brown adipose mass after 0, 3 or 12 days of CR one-way ANOVA (F_2,21=3.347, P=0.0547). (j) Percent change in intrascapular brown adipose mass compared to the average of CR one-way ANOVA (F_2,21=3.347, P=0.0547). N=8 for all groups. Data shown as±s.e.m.