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. 2017 Apr 10;7(4):e260. doi: 10.1038/nutd.2017.13

Figure 3.

Figure 3

Inhibition of β3-AR signaling prevents body weight loss and lipolysis in response to CR. (a) C57BL/6 male mice at least 12 weeks of age and 25 g were either fed AL or only 75 % of their average daily standard chow intake (CR). Mice were injected IP daily with saline or SR59230a (1 mg kg−1) before feeding. Mice were weighed daily and percent body weight change from starting body mass was calculated. Two-way ANOVA (F3,22=48.14, P<0.0001) Tukey's multiple comparisons (*P<0.05 CR saline compared to CR SR59230A days 8–12). (b) Average daily food intake over 12 days by mice fed AL either injected IP with saline or SR59230a (1 mg kg−1). Two sample t-test (P=0.783). (c) Serum glycerol levels of mice after 12 days of AL feeding or CR either injected IP with saline or SR59230a (1 mg kg−1). *P=0.011 AL saline compared to CR saline, P=0.956 AL SR59230a compared to CR SR59230a. (d) Dissected liver mass, weighed following 12 days of saline or SR59230a (1 mg kg−1) intraperitoneal injections while fed AL or on CR. **P=0.0083 AL SR59230a compared to CR SR59230a, ****P=0.0001 CR saline compared to CR SR59230a. Two-way ANOVA with Tukey's multiple comparisons. Data shown as±s.e.m. N=15 AL saline and CR saline N=8 AL SR59230a N=13 CR SR59230a.