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Interleukin-18 (IL-18) paradox in diet-induced obesity and cardiac dysfunction. Interleukin-18 (IL-18) knockout (KO) mice had a higher food intake (a) and body weight (b), and similar glucose (c) compared with wild type. IL-18 KO mice presented partially preserved systolic (d) and diastolic function (e–g) and less myocardial interstitial fibrosis (h). #P<0.05 vs wild type; *P<0.05 vs Baseline.
