Table 2.

H₂O₂ dynamic range and response time for thiol proteins. Calculation of H₂O₂ dynamic range was done with Eq. 4B, assuming 10% and 90% of target oxidation, respectively for the lower and upper limit. Calculation of the response time to H₂O₂ was done with Eq. 5B, assuming 50% of target oxidation. For PTP1B and SHP-2 data for the reactivity obtained in the presence of CO₂[26] is also shown.

Redox target	ktarget+H2O2(M−1s−1)	kswitchoff(s−1)	H2O2dynamic range (µM)	Response time to H2O2(s)
PTP1B	24	2×10−3	9–750	173
+CO2	396	2×10−3	0.6–45	173
SHP‐2	20	2×10−3	11–900	173
+CO2	167	2×10−3	1.3–108	173
Prx5	3×105	2	0.7–60	0.2
Prx2	1×107	2	0.02–1.8	0.2