Table 2. Genomic features.

	Human germline	Mouse germline	Human somatic	Mouse somatic
% of mutations
3′ UTR	0.00	1.45	0.49	0.60
5′ UTR	0.00	0.00	0.07	0.11
downstream	0.89	0.00	0.65	0.90
exonic	2.68	0.97	0.96	1.23
exonic;splicing	0.00	0.00	0.00	0.03
intergenic	50.89	60.87	55.54	62.21
intronic	35.71	34.30	32.28	31.21
ncRNA	8.93	1.93	9.52	3.00
splicing	0.00	0.00	0.02	0.00
upstream	0.89	0.48	0.45	0.71
% of exonic mutations
nonsynonymous	66.67	50.00	56.60	69.57
synonymous	33.33	50.00	37.74	28.26
stop gain	0.00	0.00	5.66	2.17
Observed Ns/S	2.0	1.0	1.65	2.54
Expected Ns/S	2.39	2.40	2.76	2.98

Distribution of mutations in genomic features and types of exonic mutations. As data on the locations of human germline mutations from ref. 14 were not available, only the mutations from ref. 13 were considered.