Table 3. Drug Condition Comparisons (p⩽0.001, t>3.0) for Preferential Neural Responses to Negative Social Feedback (Negative Social Feedback>Positive Social Feedback).

Brain region	MNI coordinates X, Y, Z	Cluster size	Peak T-value	Peak uncorrected p-value
Placebo>Oxytocin
Left superior frontal cortex	−21, 32, 55	55	5.01	<0.001
Right superior temporal gyrus	60, −4, −14	36	4.55	<0.001
Left TPJ/pSTSa	−54, −40, 7	101	4.12	<0.001
Cingulate	−12, −22, 49	202	4.11	<0.001
Left fusiform	−24, −37, −20	89	4.05	<0.001
Left OFC	−39, 29, −17	60	3.93	<0.001
Right fusiform	24, −34, −17	39	3.85	<0.001
Right fusiform/ITGa	45, −10, −23	53	3.50	<0.001
Left middle temporal gyrus	−57, −13, −17	56	3.47	<0.001
Posterior cingulate	−9, −55, 22	30	3.30	0.001
Oxytocin>Placebo
No significant activation
Placebo>Vasopressin
Left superior frontal incl.	−18, 35, 55	100	4.12	<0.001
Pre-SMAa	0, 26, 55		3.07	0.001
Anterior cingulate/MPFC	−9, 44, 28	52	3.76	<0.001
Right fusiform/ITGa	48, −13, −20	28	3.54	<0.001
Left OFC	−30, 26, −20	34	3.42	<0.001
Right OFC	45, 35, −11	50	3.33	0.001
MPFC	−3, 38, 40	26	3.31	0.001
Left TPJ/pSTSa	−54, −37, 10	46	3.29	0.001
Vasopressin>Placebo
No significant activations
Oxytocin>Vasopressin
Anterior cingulate	9, 23, 25	25	3.50	<0.001
Vasopressin>Oxytocin
Right superior temporal gyrus	39, 14, −26	32	3.75	<0.001
Posterior cingulate	−3, −31, 10	34	3.60	<0.001

Abbreviations: ITG, inferior temporal gryus; MPFC, medial prefrontal cortex; OFC, orbitofrontal cortex; pSTS, posterior superior temporal sulcus; TPJ, temporoparietal junction.

Cluster size determined by p<0.005, cluster size⩾25 for illustrative purposes in Figure 3.

^aBrain region significantly activated for negative social feedback>positive social feedback under placebo (and not oxytocin or vasopressin).