Figure 1.

fMRI activation produced by intranasal OXT administration in the mouse brain. We mapped the functional activation produced by acute intranasal OXT in the mouse (1.33 μg/mouse) using two different regression functions characterized by a sustained (a, top) and transient dynamics (b, bottom). The regressor functions used for fMRI mapping are depicted on top of each panel. Illustrative fMRI time courses in the representative regions of interest (identified by a circle in the activation maps) are also reported. OXT or vehicle were administered at time 0. Data are plotted as mean±SEM within each group. (b) Mean rCBV response elicited by OXT as quantified in the representative volumes of interest (left: sustained, right: transient; **p<0.01; ***p<0.01, Student's t-test, followed by Benjamini–Hochberg correction). Acb, nucleus accumbens; cb, cerebellum; Cg, cingulate cortex; DB, diagonal band; dCPu, dorsal portion of the caudate putamen; dHPC, dorsal hippocampus; M1, primary motor cortex; PtCtx, parietal cortex; PFC, prefrontal cortex; Pir, piriform cortex; rCBV, relative cerebral blood volume; Sp, septum; Th, thalamus; vHPC, ventral hippocampus; VP, ventral pallidum.