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. 2017 Feb 15;42(7):1435–1446. doi: 10.1038/npp.2017.7

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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(a) MIA induces long lasting changes in cerebellar cytokines throughout development. Multiplex array showing the differential expression of various immune molecules in the cerebellar lysates of MIA offspring compared to control values at different stages of development. The average fold-change and SEM in cytokine concentration in cerebellum from MIA offspring compared to control values is plotted. Values from MIA offspring are either black, red, or green, and the control values are superimposed in clear bars. Red and green bars indicate statistically significant increases or decreases, respectively, compared to controls (P<0.05). Increases are shown above 1 and decreases, below 1. Values of fold change and SEMs are included in Supplementary Table 2. (b) A heat map is used to summarize the results for MIA-induced changes in cytokines and chemokines. The degree of change is indicated by the depth of color as indicated in the lower panel. ND = below the level of detection.