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. 2017 Feb 15;42(7):1435–1446. doi: 10.1038/npp.2017.7

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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MIA decreases glutamatergic synapse density on cerebellar Purkinje neuron from newborn offspring. (a and b) GFP-expressing Purkinje neurons in 14 day mixed cerebellar cultures from control and MIA offspring, respectively. Cells were immunostained for the excitatory presynaptic marker VGluT1 and the postsynaptic marker GluRδ2. (c) There are fewer dendritic spines with GluRδ2 puncta in MIA cultures. (d) There are fewer synapses (spines with GluRδ2 and VGluT1) in MIA cultures. Arrowheads in merged images point to spines without GluRδ2 or VGluT1 (green), spines with GluRδ2 only (red), or spines with GluRδ2 and VGluT1 (blue). *p<0.05.