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. 2017 Apr 12;15(6):3521–3528. doi: 10.3892/mmr.2017.6472

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Copyright: © Ge et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effect of SNS-032 combined with ZD55-TIS on pro-apoptotic signaling elements in PANC-1 cells. PANC-1 cells were treated with ZD55-TIS (8 MOI) or/and SNS-032 (160 ng/ml). The combination of ZD55-TIS and SNS-032 downregulated the protein expression of CDK-2, −7, and −9, and XIAP, Mcl-1 and Bcl-2. ZD55-TIS, ZD55-TRAIL-IETD-Smac; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; IETD, isoleucine-aspartate-threonine-glutamate; Smac, second mitochondria-derived activator of caspase; CDK, cyclin-dependent kinase; Mcl-1, Bcl-2 family apoptosis regulator; XIAP, X-linked inhibitor of apoptosis; Bcl-2, Bcl-2 apoptosis regulator.