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. 2010 Sep 9;2:121–137. doi: 10.2147/eb.s9902

Figure 5.

Figure 5

Retinal sections showing the distribution of protein gene product 9.5 (PGP 9.5, red) with glial fibrillary acid protein (GFAP, green) and DAPI nuclear stain (blue). Inset monochromatic images depict PGP 9.5 alone. In normal retina (A), PGP 9.5 is strongly expressed among both somata and plexiform layers of horizontal, amacrine and ganglion cells. B) Injection of Aβ42–1 reverse sequence produced modest downregulation of PGP 9.5 and mild upregulation of GFAP after 48 hours. C) 48 hours after injection of Aβ1–4, PGP 9.5 is clearly downregulated, particularly within large somata. GFAP levels are also markedly increased at 48-hour postinjection. D) 1 month after injection of Aβ1–42 PGP 9.5 expression is largely restored within the atrophied inner plexiform layer and small somata; however, the reduction in labeling of large somata persists. All Aβ1–42 treatments were preaggregated for 8 days. Scale bar = 100 μm.