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. 2012 Mar 13;4:13–25. doi: 10.2147/EB.S29401

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© 2012 Baughman et al, publisher and licensee Dove Medical Press Ltd

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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Magnetic resonance imaging images of manifestations of neuro-ophthalamic sarcoidosis. (A) Coronal fat-suppressed T1-weighted post-contrast and (B) sagittal T2-weighted images demonstrate an ill-defined contrast-enhancing, low T2-signal inferior right orbital mass (arrows) surrounding the insertion of the inferior rectus muscle. Subsequent biopsy revealed granulomatous inflammatory tissue compatible with sarcoid. In another patient, coronal fat-suppressed T1-weighted post-contrast images reveal abnormal enhancement along the bilateral intraconal (C) and pre-chiasmal (D) optic nerves. In a third patient, (E) a coronal fat-suppressed T1-weighted post-contrast image reveals thick abnormal enhancement about the bilateral optic nerves (short arrows) and more extensively along the bilateral leptomeninges and dura (long arrows). In a fourth patient, presenting with blindness, a coronal pre-contrast T1-weighted image (F) and corresponding post-contrast image (G) demonstrate a swollen optic chiasm (short arrows) with thick leptomeningeal enhancement about and beyond the chiasm bilaterally (long arrows). In a fifth patient, a coronal fat-suppressed T1-weighted post-contrast image (H) reveals asymmetric right-sided involvement of the optic chiasm (arrow). In a sixth patient, presenting with right sided cranial nerves III and V abnormalities, an axial fat-suppressed T1-weighted post-contrast image (I) reveals involvement of the right cavernous sinus (short arrows) and along the cisternal portion of the ipsilateral trigeminal nerve (long arrow).

Magnetic resonance imaging images of manifestations of neuro-ophthalamic sarcoidosis. (A) Coronal fat-suppressed T1-weighted post-contrast and (B) sagittal T2-weighted images demonstrate an ill-defined contrast-enhancing, low T2-signal inferior right orbital mass (arrows) surrounding the insertion of the inferior rectus muscle. Subsequent biopsy revealed granulomatous inflammatory tissue compatible with sarcoid. In another patient, coronal fat-suppressed T1-weighted post-contrast images reveal abnormal enhancement along the bilateral intraconal (C) and pre-chiasmal (D) optic nerves. In a third patient, (E) a coronal fat-suppressed T1-weighted post-contrast image reveals thick abnormal enhancement about the bilateral optic nerves (short arrows) and more extensively along the bilateral leptomeninges and dura (long arrows). In a fourth patient, presenting with blindness, a coronal pre-contrast T1-weighted image (F) and corresponding post-contrast image (G) demonstrate a swollen optic chiasm (short arrows) with thick leptomeningeal enhancement about and beyond the chiasm bilaterally (long arrows). In a fifth patient, a coronal fat-suppressed T1-weighted post-contrast image (H) reveals asymmetric right-sided involvement of the optic chiasm (arrow). In a sixth patient, presenting with right sided cranial nerves III and V abnormalities, an axial fat-suppressed T1-weighted post-contrast image (I) reveals involvement of the right cavernous sinus (short arrows) and along the cisternal portion of the ipsilateral trigeminal nerve (long arrow).