Table 1.
Genes associated with ocular disease
| Gene | First author | Comment |
|---|---|---|
| DRB1*0401 | Rossman102 | Association with eye disease in African Americans but not Caucasians |
| HSP/Hom | Spagnolo20 | Associated with uveitis in Europe |
| CTLA-4 | Hattori21 | Study in Japan |
| MMP-1 | Ninomiya22 | Study in Japan, found no increased risk of disease |
| NOD2 | Okafuji24 | Association between early onset sarcoidosis with uveitis as well as patients with Blau’s syndrome |
Abbreviations: HSP/Hom, heat shock protein 70/Hom; CTLA-4, cytotoxic T-lymphocyte antigen 4; MMP-1, matrix metalloproteinase-1; NOD2, nucleotide-binding oligomerization domain 2 gene.