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. 2017 Apr 12;15(6):3599–3606. doi: 10.3892/mmr.2017.6476

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Exposure to γ-rays altered GDF-15 mRNA expression levels in AHH-1 cells. (A) AHH-1 cells were irradiated with 0–10 Gy ⁶⁰Co γ-rays at a dose rate of 1 Gy/min. Cells were collected for analysis 8–168 h post-irradiation. Relative GDF-15 mRNA expression levels were assessed using RT-qPCR. GDF-15 mRNA expression levels were significantly upregulated 8–120 h following irradiation compared with the control group (0 Gy). (B) AHH-1 cells were irradiated with 3, 5 or 8 Gy of ⁶⁰Co γ-rays at a dose-rate of 0.5, 1 and 2 Gy/min. Cells were collected for analysis 48 h post-irradiation. Relative GDF-15 mRNA expression levels were assessed using RT-qPCR. Alterations in GDF-15 expression depended on radiation dose, regardless of the dose rate. Data are expressed as the mean ± standard error of the mean of three independent experiments. *P<0.05 vs. 0 Gy group. GDF, growth/differentiation factor; RT-qPCR, reverse transcription-quantitative polymerase chain reaction.