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. 2017 May 3;15(6):4273–4279. doi: 10.3892/mmr.2017.6543

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Copyright: © Ren et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — GTP-RhoA inhibition has no effect on Taxol-induced MT bundling, but partially inhibits the Taxol-induced increase in G2/M cell number. (A) Western blotting demonstrated that transfection with the RhoAT19N mutant or using RhoA inhibitor (C3 transferase) significantly decreased GTP-RhoA expression. (B and C) The combination of Taxol with RhoAT19N plasmid or C3 transferase decreased the Taxol-induced increase in the proportion of cells in the G2/M phase however, (D) it had no marked effects on Taxol-induced MT bundling. Data are presented as the mean ± standard deviation of three independent experiments. *P<0.05 vs. control; ^#P<0.05 vs. Taxol. Scale bar=10 µm. GTP, guanosine triphosphate; RhoA, Ras homology gene family, member A; MT, microtubule; MF, actin/myosin microfilaments.