Table 3.

Comparison of the diagnostic and predictive ability of plasma ZIC1, HOXD10 and RUNX3 methylation, when used alone or combined, in gastric cancer and intraepithelial neoplasia.

	Sensitivity (95% CI)	Specificity (95%CI)	Youden index
GC
ZIC1	69.5% (60.7%-77.0%)	69.2% (60.0%-77.1%)	0.386
HOXD10	48.1% (39.3%-57.0%)	80.0% (71.5%-86.5%)	0.281
RUNX3	42.7% (34.2%-51.7%)	79.2% (70.6%-85.8%)	0.219
ZIC1+HOXD10	82.4% (74.6%-88.3%)	58.3% (49.0%-67.2%)	0.408
ZIC1+RUNX3	83.2% (75.5%-89.0%)	57.5% (48.1%-66.4%)	0.407
HOXD10+RUNX3	72.5% (63.9%-79.8%)	65.0% (55.7%-73.3%)	0.375
ZIC1+HOXD10+RUNX3	91.6% (85.1%-95.5%)	50.0% (40.8%-59.2%)	0.416
GnI
ZIC1	64.2% (56.8%-70.9%)	87.5% (76.3%-94.1%)	0.517
HOXD10	43.9% (36.7%-51.3%)	92.2% (82.0%-97.1%)	0.360
RUNX3	41.2% (34.1%-48.6%)	93.8% (84.0%-98.0%)	0.349
ZIC1+HOXD10	78.6% (71.9%-84.1%)	82.8% (70.9%-90.7%)	0.614
ZIC1+RUNX3	80.2% (73.6%-85.5%)	84.4% (72.7%-91.9%)	0.646
HOXD10+RUNX3	68.4% (61.2%-74.9%)	85.9% (74.5%-93.0%)	0.544
ZIC1+HOXD10+RUNX3	89.8% (84.4%-93.6%)	79.7% (67.4%-88.3%)	0.695

ZIC1, Zinc finger of the cerebellum 1; HOXD10, Homeobox D10; RUNX3, runt-related transcription factor 3; GC, gastric cancer; GnI, gastric cancer and intraepithelial neoplasia.