Figure 1.

Clinical Samples included in the present study *As our study was case-control, only the 87 controls matched with cases were assessed in the work. ** For counting of subjects evaluated for p53 and p16 proteins expression by IHC was considered that individuals with at least one analysis to the tissues for the control group (proximal and/or distal esophageal tissues) and tumor tissue for case group. *** This analysis could not be performed for all individuals included in the study due to lack of material.