Table 3.

Univariate log-rank analysis for important clinicopathological variables and EphA4 expression

Parameter		No. of case	DSS		LRFS		MeFS
			No. of event	P value	No. of event	P value	No. of event		P value
Gender	Male	108	20	0.9026	7	0.2250	17		0.3520
	Female	64	11		20		14
Age	<70	106	19	0.8540	18	0.6615	20		0.7427
	≧70	66	12		9		11
Pre-Tx tumor status	T1-T2	81	10	0.0776	10	0.2261	11		0.1745
	T3-T4	91	21		17		20
Pre-Tx nodal status	N0	125	19	0.0711	15	0.0070*	19		0.0973
	N1-N2	47	21		12		12
Post-Tx tumor status	T1-T2	86	7	0.0006*	7	0.0040*	8		0.0033*
	T3-T4	86	24		20		23
Post-Tx nodal status	N0	123	21	0.5998	16	0.1320	20		0.4634
	N1-N2	49	10		11		11
Vascular invasion	Absent	157	25	0.0184*	21	0.0028*	27		0.4470
	Present	15	6		6		4
Perineural invasion	Absent	167	29	0.2559	25	0.0940	30		0.9083
	Present	5	2		2		1
Tumor regression grade	Grade 0-1	37	13	0.0038*	10	0.0090*	14		0.0006*
	Grade 2~3	118	17		17		16
	Grade 4	17	1		0		1
EphA4 expression	Low Exp.	86	9	0.0009*	11	0.0719		6	0.0001*
	High Exp.	86	22		16			25

DSS, disease-specific survival; LRFS, local recurrence-free survival; MeFS, metastasis-free survival; *, statistically significant