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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Environ Mol Mutagen. 2017 Apr;58(3):146–161. doi: 10.1002/em.22083

Figure 1.

Figure 1

Fold-increase responses for four biomarkers are graphed against chemical concentration (log10). The graphs are aggregate data for 231 experiments conducted by seven laboratories. The data are coded according to genotoxic MoA: clastogens = red circles, aneugens = blue squares, and non-genotoxicants = green triangles. These graphs support the fact that these biomarkers as transferable across sites, and suggest that different response profiles among chemical classes should be valuable for elucidating genotoxic mode of action.