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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Environ Mol Mutagen. 2017 Apr;58(3):146–161. doi: 10.1002/em.22083

Figure 3.

Figure 3

Color-coded results summarizing the Global Evaluation Factors approach for determining chemicals’ predominant genotoxic mode of action. The data are organized according to chemical (A = aneugen, C = clastogen, and NG = non-genotoxicant) as well as laboratory (LIT = Litron, BAY = Bayer, ORI = Orion, PFI = Pfizer, ROC = Roche, SAN = Sanofi, SER = Servier). The red color is indicative of a significant clastogen-sensitive biomarker response, blue is indicative of a significant aneugen-sensitive biomarker response, violet is indicative of a pan-genotoxicant biomarker response (i.e., p53 at 24 hrs), and white indicates no significant response. The right-most columns indicate the predominant MoA call (red for clastogen, blue for aneugen, white for non-genotoxicant. As described in the Materials and Methods section, a clastogen or aneugen call requires two or more supportive biomarker responses.