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γH2AX (4 hr) and p53 (4 hr and 24 hr) responses are graphed for menadione-treated TK6 cells. Whereas the GEFs and lab-specific cutoff value approaches failed to recognize these modest responses as clastogenic, the multinomial logistic regression model interpreted the three clastogen-responsive biomarker results as clear evidence of clastogenic activity (probability > 90%).
