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The different implications of ECS in endometriosis and pain. High levels of CB1 receptors and endocannabinoid ligands have been observed in endometriosis patients. Although this occurs as a mechanism to reduce inflammation, low CB1 levels in the tissue act as a negative feedback loop and disrupt the pain mechanism. However, several natural and synthetic agonists modulate ECS and reduce endometriosis-associated pain. ECS, endocannabinoid system; PEA, N-palmitoylethanolamine.
