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The schematics showing the non-specific interactions between the aptamer on the AFM tip and the OMP on the outer membrane surface during the DFS measurements. a During the unbinding process, the lipid molecules (in gray) may generate non-specific force to the OMP (in green) due to the elastic property of the outer membrane. b When the OMP is in the area of the OMV formation, the measured extension can be significant different from other areas
