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. 2017 Apr 7;14(4):356–366. doi: 10.7150/ijms.18382

Figure 5.

Figure 5

Effects of docetaxel and YK-4-279 alone or in combination on the levels of ETV1, AR, PSA, p-STAT3, survivin, Bcl-2 and p-Akt in LNCaP and PC-3 cells. LNCaP and PC-3 cells were cultured at a density of 1 × 105 cells/ml in 100 mm tissue culture dishes (10ml/dish) for 24 h. The cells were then treated with docetaxel (0.5nM) and YK-4-279(0.5µM) alone or in combination for 24h (for analysis of p-Akt, survivin, PSA, p-STAT3 and AR) and 48 h (for analysis of Bcl-2). The levels of AR,Bcl-2, p-STAT3, PSA,p-Akt and survivin were determined by the Western blot analysis. The band density was measured and normalized for actin.