Table 1.
Effect of docetaxel and YK-4-279 alone or in combination on LNCaP and PC-3 cell apoptosis
| Treatment | Apoptotic cells (%) | Dead cells (%) | ||
|---|---|---|---|---|
| LNCaP | PC-3 | LNCaP | PC-3 | |
| Control | 2.32±0.31 | 3.38±0.89 | 3.67±1.15 | 4.01±0.55 |
| Docetaxel | 4.95±0.57 | 4.38±0.86 | 5.33±0.58 | 4.88±0.78 |
| YK-4-279 | 5.52±0.84 | 4.72±0.81 | 6.67±0.58 | 4.94±0.38 |
| Combination | 17.03±3.12*** | 17.04±0.64*** | 18.67±0.15*** | 19.96±2.11*** |
LNCaP or PC-3 cells was cultured at a density of 2 × 10 4 cells/ml for 24 h. The cells were then treated with docetaxel (0.5nM) and YK-4-279(0.5µM) alone or in combination for 72h. Apoptosis was determined by morphological assessment. Each value represents mean±S.E from three separate experiments. Significant numbers of apoptotic cells between a combination group and a single-agent-treated group were analyzed by ANOVA with Tukey-Kramer multiple comparison test (*p<0.05, **p<0.01, ***p<0.001).