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. 2017 Mar 24;7(6):1407–1421. doi: 10.7150/thno.18262

Figure 5.

Figure 5

Schematic illustration of the miRNA-mediated interactions between cancer cells and dendritic cells (DCs). The overall interactions are mediated by tumor-derived circulating miR-410-5p and DC-derived miR-410-3p, both of which share the same precursor (pre-miR-410). Under the stimulus of cancer cell antigens, DCs produce miR-410-3p, which functions to target VEGF for suppressing tumor angiogenesis (A). However, cancer cells express miR-410-5p and secrete it into the peripheral blood. The circulating miR-410-5p is then transported into DCs by means of association with AGO2 protein. Once inside DCs, the miR-410-5p then forms a duplex with miR-410-3p through complementary pairing across 12 bases. The duplex formation results in the degradation of miR-410-3p, which promotes the tumor angiogenesis and thus favors the tumor progression (B).