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. 2017 Apr 6;7(6):1511–1523. doi: 10.7150/thno.18401

Figure 4.

Figure 4

Inhibition effects of the peptides on tumor cell migration and angiogenesis. (A) Microscopic images of the migration of U87MG cells treated with PTX, Sunitinib RWrNM, RWr and c(RGDyK). Scale bar: 100 μm (B) Microscopic images of the invasion of U87MG cells treated with PTX, Sunitinib, RWrNM, RWr and c(RGDyK). Scale bar: 100 μm (C) Quantitative analysis of the different cells crossing the transwell membrane after the treatments with peptides and anticancer drugs. *P < 0.05 (D) Quantification of the invasion rates of different cell lines after treatments with peptides and anticancer drugs. (E) Quantification of cell adhesion rates in different cell lines treated with PTX, Sunitinib, RWrNM, RWr and c(RGDyK). *P < 0.05 (F) Effects of these peptides on angiogenesis in Chick chorioallantoic membrane model. Relative vessel numbers of different treatment groups were plotted. Scale bar: 5 mm (G) Western blot analysis of the levels of FAK, p-FAK, PI3K, p-PI3K, Ras and p-Ras proteins in U87MG cells after incubated with RWrNM, RWr and c(RGDyK).