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. 2017 Apr 10;7(6):1719–1734. doi: 10.7150/thno.18340

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(A) Penetration of HAss nanogels in tumor at 1 h (up), 6 h (middle) and 24 h (bottom) post-injection. The scale bar is 100 μm. (B) Immunofluorescence staining sections of RHAMM (green) expression in tumor, RBITC-HAss nanogels (red) penetrated in tumor at 24 h post-injection. All cell nuclei are not shown in this figure. The scale bar is 100 μm. (C) Bio-distribution of DOX for DOX-loaded HAss nanogels in H22 subcutaneous tumor-bearing mice. The values were presented as the percentage of ID per gram of collected organs (mean ± s.d., n = 3). (D) Tumor volume of the mice with different administrations as indicated (mean ± s.d., n = 10). ** represents P < 0.01. (E) The weight plot of mice with different administrations (mean ± s.d., n = 10).