Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Functional characterization of the methylated promoters in UM.
| Gene | The Percentage of patients with hypermethylation | Function | Reference |
|---|---|---|---|
| RASSF1A | 91% | RAS-associated domain family | [53-60] |
| MGMT | 10%-30% | O6-methylguanine-DNA methyltransferase | [67] |
| DcR1, DcR2 | 91%-97% | Receptors for TRAIL | [68] |
| p16/INK4a | / | Stabilizer of the tumor suppressor protein | [8, 44-52] |
| CXCR4, CCR7 | / | Hypermethylation of this gene can inhibit metastasis | [69] |
| RASEF | 46%-54% | RAS pathway | [61-63] |
