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. 2017 Apr 8;13(4):505–517. doi: 10.7150/ijbs.18834

Figure 4.

Figure 4

Effects on ERK, AKT and Hippo pathway in breast cancer cells upon inhibition of HSP90. A. Investigation of AKT (p-AKT), ERK (p-ERK), and YAP (p-YAP) levels in TNBC cells and ERα positive breast cancer cells upon 0.1μM and 1μM HSP90 inhibitor 17-DMAG treatment. B. Inhibition of HDAC6 with 1μM Tubacin led to a decrease of YAP with an increase in tubulin acetylation, AKT and ERK phosphorylation. C. Effects on cell viability of breast cancer cells upon YAP silencing using siRNAs. Each group was compared to control group, *P<0.05.